Evidence-based Treatment for Depression, Anxiety and Burnout

Backed by Rigorous Clinical Research

Meru Health is committed to cutting-edge research conducted with integrity as a way to continuously improve our program.

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Published research with


Evidence based treatment modalities.

The treatment modalities and approaches that we utilize have been validated by high quality studies and show significant proof of efficiency. Simultaneously we look to develop and experiment new treatment approaches backed by rigorous science.


Evidence-based treatment methods

  • Cognitive behavioral therapy (CBT)

  • Behavioral activation therapy

  • Mindfulness-based cognitive therapy (MBCT)

  • Mindfulness based stress reduction

Treatment methods with Preliminary evidence

  • Heart rate variability biofeedback

  • Nutritional psychiatry

  • Sleep medicine

Clinical outcomes


Depression symptom reduction

Measured with industry standard PHQ-9 SCALE 

On average, our patients experience a 54% decrease in depressive symptoms. Improvements in depressive symptoms are long-lasting, with our patients maintaining or even continuing to improve over the 12 months following the end of the program.

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Anxiety symptom reduction

Measured with industry standard GAD-7 SCALE 

On average, our patients experience a 41% reduction in anxiety symptoms. Improvements in anxiety symptoms are maintained up to 6 months after the end of the treatment.


Estimated marginal means for PHQ-9 and GAD-7. The scores across all available timepoints. The dotted line indicates the last week of the Meru Health Program. Error bars represent standard error of the mean (SEM). n=102 Meru Health program participants*

Treatment completion rate


89% of Meru Health patients complete the program with significant symptom reduction. These real-world completion rates appear to be slightly higher than those from research studies of industry standard alternatives such as psychotherapy and antidepressant treatment methods. Although a head-to-head study of the Meru Health program versus these alternatives has not yet been conducted, it is believed that these superior completion rates among those participating in the Meru Health program would prevail.

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  • Cooper, A. A. & Conklin, L. R. (2015). Dropout from individual psychotherapy for major depression: A meta-analysis of randomized clinical trials. Clinical Psychology Review, 40, 57-65.
  • Rutherford, B. R., Cooper, T. M., Persaud, A., Brown, P. J., Sneed, J. R., & Roose, S. P. (2013). Less is more in antidepressant clinical trials: a meta-analysis of the effect of visit frequency on treatment response and drop-out. The Journal of clinical psychiatry, 74(7), 703.

Clinically meaningful reduction in depressive symptoms


Immediately after treatment, 48% of patients in the Meru Health program experience a clinically meaningful improvement in depressive symptoms. Proportions of improved patients in the Meru Health program are similar if not better than those reported in CBT and antidepressant trials.

The improvements experienced by Meru Health patients are long-lasting, with 60% of patients experiencing a clinically meaningful reduction in depressive symptoms at 12 months post treatment.

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  • Amick, H. R., Gartlehner, G., Gaynes, B. N., Forneris, C., Asher, G. N., Morgan, L. C., . . . Lohr, K. N. (2015). Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: Systematic review and meta-analysis.
  • Economides, M., Ranta, K., Nazander, A., Hilgert, O., Goldin, P. R., Raevuori, A., & Forman-Hoffman, V. (2019). One-year outcomes of a therapist-supported, smartphone-based intervention for elevated symptoms of depression and anxiety.
  • Goldin, P. R., Lindholm, R., Ranta, K., Hilgert, O., Helteenvuori, T., & Raevuori, A. (2019). Feasibility of a Therapist-Supported, Mobile Phone–Delivered Online Intervention for Depression: Longitudinal Observational Study. JMIR formative research, 3(1), e11509.
  • Simon, G.E., Ding, V., Hubbard, R., Fishman, P., Ludman, E., Morales, L., … Savarino, J. (2012). Early dropout from psychotherapy for depression with group- and network-model therapists. Administration and policy in mental health, 39(6), 440–447.

HRV biofeedback for depression and anxiety

Meru Health is the first company to combine HRV-Biofeedback into a remote and clinician supported treatment program for depression and anxiety. Meru Health has worked with leading academia and researchers to prove the efficacy, safety and feasibility of this approach. Below you’ll find a poster that was presented in March 2019 at the annual biofeedback conference of The Association for Applied Psychophysiology and Biofeedback (AAPB). Meru Health has submitted a controlled study for peer-review on Feasibility and efficacy of the addition of heart rate variability biofeedback to a remote digital health intervention for depression. The pre-archived paper can be also found below.

Read study

Download poster


Dr. Inna Khazan , faculty at Harvard Medical School, licensed clinical psychologist, board certified in biofeedback, Clinical Advisor at Meru Health

Dr. Inna Khazan, faculty at Harvard Medical School, licensed clinical psychologist, board certified in biofeedback, Clinical Advisor at Meru Health

There is a technique that has been showing some really promising results in treating patients with depression, anxiety, and burnout called heart rate variability biofeedback (HRV-B). Briefly, heart rate variability (HRV) measures the difference in time that passes from one heart beat to the next. HRV is an important indicator of your body’s ability to regulate itself, during times of stress and during times of relaxation. This ability to self-regulate includes regulation of your moods and emotions. People with various medical and/or mental health problems, such as depression and anxiety, tend to have low HRV, which means that their bodies have trouble regulating themselves at times of stress and allowing them to recover properly during times of relaxation.

HRV-B strengthens your body’s ability to regulate your physical and emotional activation, allowing you to respond to stressful situations in healthier ways. HRV-B involves learning a special breathing technique which increases your HRV, and then practicing this technique while monitoring your progress with a device that measures different aspects of HRV. Regular practice of HRV-B can strengthen your ability to respond to stressful situations in more helpful ways and recover more quickly when they are over. Several studies have shown the benefits of using HRV-B to treat people who have high levels of depression, anxiety, and other types of stress.

Program engagement

Patients are strongly engaged with the Meru Health program and rate Meru Health therapists highly. Meru Health therapists and psychiatrists monitor patients and engage patients almost on a daily basis.
Average therapist rating


On average participants rate their highly 4.5/5 on a scale of 1-5.
Average engagement


On average participants engage with the program on 4.4 days out of 7 throughout the 12-week program
Time spent in treatment


On average, participants spend 20-25 hours interacting with their therapist or treatment practices. This equals to 25-30 in-person therapy visits.
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Research pipeline


Meru Health has several cutting-edge research projects in various stages of development with collaborators around the globe

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Published Peer-Reviewed Studies

A Feasibility of a Therapist-Supported, Mobile Phone–Delivered Online Intervention for Depression: Longitudinal Observational Study - Goldin PR, Lindholm R, Ranta K, Hilgert O, Helteenvuori T, Raevuori

Read Study

Long-Term Outcomes of a Therapist-Supported, Smartphone-Based Intervention for Elevated Symptoms of Depression and Anxiety: Quasiexperimental, Pre-Postintervention Study - Economides M, Ranta K, Nazander A, Hilgert O, Goldin PR, Raevuori A, Forman-Hoffman V

Read Study




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